Endocrine Abstracts

Adrenomedullin (AM) was discovered in the adrenal gland in 1993 by Kitamura and colleagues. Since then it has been found in many other tissues including in skin. We know from our recent studies that AM regulates (in vitro) the secretion of cytokines and growth factors, known to be involved in tissue repair, from endothelial and skin cells. The present study was designed to establish whether AM levels in skin were increased following wounding in vivo.A we...

Cutaneous injury triggers a complex series of biological processes which lead to tissue repair and comprise the mechanism termed wound healing. Various growth factors and cytokines are involved in the multiple stages of wound healing. Keratinocyte growth factor (KGF) is secreted by skin fibroblasts and acts locally to induce cell proliferation. During wound healing KGF's role is as a re-epithelialising agent working in conjunction with pro-inflammatory cytokines such as interl...

Adrenomedullin (AM) is a multifunctional peptide hormone which plays a significant role in vasodilation and angiogenesis, implicating it in hypertension as well as in carcinogenesis. AM exerts its effects via the Calcitonin Receptor-Like Receptor (CLR) complexed with either Receptor Activity Modifying Protein (RAMP) 2 or 3.The aim of the present study is to investigate the biological actions, functions and possible target genes of AM in immortalized Huma...

Adrenomedullin (ADM) is a multifunctional peptide which plays a significant role in vasodilation, angiogenisis and septic shock. It exerts its effects via the calcitonin receptor-like receptor (CRLR) in combination with either receptor associated protein (RAMP) 2 or 3. However the regulation of the ADM receptors is still widely unknown (1). In the present study the effects of adrenomedullin on immortalized Human Microvascular Endothelial Cells (HMECs) was investigated. Endothe...